Simulation Plus[SLP] SLP New Publications, 4th Mar 2025

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SLP 소프트웨어와 관련하여 새롭게 업데이트된 논문을 소개드립니다.


Molecular Precision Medicine: Application of Physiologically Based Pharmacokinetic Modeling to Predict Drug–Drug Interactions Between Lidocaine and Rocuronium/Propofol/Paracetamol.

Silva A, Mourão J, Vale N. (2025) International J Molecular Sciences 26(4):1506

Keywords: gastroplus, pbpk modeling, physiologically based pharmacokinetics, ddi, cytochrome p450, dose selection


Physiologically based pharmacokinetic model for oxcarbazepine active metabolite to predict pharmacokinetics in paediatric patients with renal impairment and adjust dosages.

Ke CJ, Liu ST, Qian YD, You X, Lin RF, Lin CH, Huang PF, Lin WW. (2025) Br J Clin Pharmacol. Feb 17

Keywords: 

Keywords: gastroplus, pbpk modeling, physiologically based pharmacokinetics, metabolite tracking, population simulations, children, pediatrics, disease state, renal impairment, dose optimization


Hansen Solubility Parameters, Computational, and Thermodynamic Models for Tofacitinib Citrate Solubility in Neat Mono Solvents, and GastroPlus Based Predicted In Vivo Performance of Subcutaneous Solution in Humans.

Ehsan I, Shahid M, Natesan S, Faruk A, Sood AK, Khan T. (2025) AAPS PharmSciTech. Feb 18;26(3):64

Keywords: gastroplus, pbpk modeling, mechanistic absorption, physiologically based biopharmaceutics, formulation design, subq


Roles of Supersaturation and Liquid–Liquid Phase Separation for Enhanced Oral Absorption of Poorly Soluble Drugs from Amorphous Solid Dispersions.

Kawakami K. (2025) Pharmaceutics 17(2):262

Keywords: gastroplus, pbpk modeling, mechanistic absorption, acat, formulation design, biopharmaceutics assessment


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